The prevalence of endoparasites, their control and clinical relevance in donkeys can often cause confusion and concern to vets and owners alike. While donkeys can be affected by the same parasite species as horses, infection characteristics, presenting signs and symptoms of disease can differ. Donkeys do not always show obvious signs of disease until it is severe so it is important to know what to look out for when clinically assessing a donkey and how best to diagnose potential infection with parasites. There is a limited selection of anthelmintic products available for use in the donkey, so prescribing using the cascade is sometimes warranted. Careful consideration should be given to the choice and frequency of anthelmintic treatments in order to balance controlling disease with preserving anthelmintic efficacy.